SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent
نویسندگان
چکیده
منابع مشابه
Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization*
Ras and Rho small GTPases possessing a C-terminal polybasic region (PBR) are vital signaling proteins whose misregulation can lead to cancer. Signaling by these proteins depends on their ability to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid moiety and subsequent trafficking to cellular membranes. There is little previous evidence that cellular si...
متن کاملSmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.
SmgGDS is an atypical guanine nucleotide exchange factor (GEF) that promotes both cell proliferation and migration and is up-regulated in several types of cancer. SmgGDS has been previously shown to activate a wide variety of small GTPases, including the Ras family members Rap1a, Rap1b, and K-Ras, as well as the Rho family members Cdc42, Rac1, Rac2, RhoA, and RhoB. In contrast, here we show tha...
متن کاملThe SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer.
UNLABELLED Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. SmgGDS is a guanine nucleotide exchange factor that activates RhoA and RhoC in vitro. We previously reported that two splice variants of SmgGDS, SmgGDS-607, and SmgGDS-558, have different characteristics in binding and transport of small GTPases. To define the role of SmgGDS in breast cancer, we tested the expre...
متن کاملRhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
Recent studies showed that specific isoprenoid modification may be critical for RhoB subcellular location and function. Therefore, we determined whether the function of the highly related RhoA protein is also critically dependent on specific isoprenoid modification: (a) in contrast to observations with RhoB or Ras proteins, where farnesylated and geranylgeranylated versions showed differences i...
متن کاملA new signaling paradigm to control the prenylation and trafficking of small GTPases
Members of the Ras and Rho families of small GTPases regulate diverse signaling pathways that promote normal physiological processes as well as diseases such as cancer. The localization of small GTPases in distinct subcellular regions defines which signaling pathways they activate, thus defining their participation in disease. The plasma membrane is viewed as the region of highest activity for ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 2018
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.8b00567